13. D'un chocolat doux comme un baiser au contrôle de la reproduction des Mammifères

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Por Yves Muller descoberto pelo Player FM e nossa comunidade - Os direitos autorais são de propriedade do editor, não do Player FM, e o áudio é transmitido diretamente de seus servidores. Toque no botão Assinar para acompanhar as atualizações no Player FM, ou copie a feed URL em outros aplicativos de podcast.

Cette 13ème chronique biologique démarre dans la ville de Hershey aux États-Unis, où l’on trouve une chocolaterie qui fabrique des « Hershey’s Kisses » (baisers d'Hershey). Et à partir de ces chocolats doux comme des baisers, je vous propose un voyage dans l’histoire des sciences à la découverte du gène KISS-1 et des kisspeptines. Cette chronique vous amènera à comprendre les mécanismes de contrôle neuroendocrinien de la reproduction des Mammifères et elle vous montrera que les kisspeptines jouent un rôle le rôle essentiel dans ces mécanismes.

Auteur : Yves Muller – Professeur Agrégé de classe exceptionnelle - Docteur en Neurosciences - Université de Montpellier

Biological Chronicles - From sweet chocolate like a kiss to mammalian reproductive control

This 13th biological chronicle presents the kisspeptin system. The kisspeptin system is believed to be requisite for normal GnRH secretion, serving as a “gatekeeper” of puberty and helping to mediate the effects of sex steroids on GnRH secretion. Kisspeptin was originally called metastin because of its ability to suppress metastatic spread of human melanomas. However, in recognition of its discovery at Pennsylvania State University in Hershey, Pennsylvania, it was later named kisspeptin after Hershey’s chocolate Kisses.

Références :

- Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (1996). "KiSS-1, a novel human malignant melanoma metastasis-suppressor gene" - Journal of the National Cancer Institute ; 88: 1731–7

- Kotani M, Detheux M, Vandenbogaerde A et al. (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 - J Biol Chem ; 276:34631–34636

- Ohtaki T, Shintani1 Y, Honda S et al. (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor - Nature ; 411:613–617

- Han SK, Gottsch ML, Lee KJ et al. (2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty - J Neurosci ; 7:11349–11356

- Dhillo WS, Chaudhri OB, Thompson EL et al. (2007) Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle - J Clin Endocrinol Metab ; 92:3958–3966

- George JT, Veldhuis JD, Roseweir AK et al. (2011) Kisspeptin is a potent stimulator of LH and increases pulse frequency in men - J Clin Endocrinol Metab ; 96:1228–1236

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