How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome
MP3•Home de episódios
Manage episode 401110078 series 2631947
Conteúdo fornecido por Sano Genetics. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Sano Genetics ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.
Summary:
0:00 Introduction
01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far
02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics
05:57 The impacts of non-coding regions of the genome and the outcome of deletions
08:20 How long it takes to make chromosomes, what does it cost, and what can we expect from the future of chromosome engineering
10:03 The inspiration behind Neochromsome and Leslie’s transition to industry from academia
13:05 From understanding the fundamentals of the genome to identifying industrial applications for genome-scale engineering
16:46 Potential gene therapy applications for the NeoYeast and NeoVector products
19:10 The power of delivering to cells using a 10-150 kilobase payload compared with lentivirus vectors
20:05 An explanation of yeast as a compact genome with few introns
21:48 How Neochrosome has developed a genome-rewritten yeast designed for incorporating non-canonical amino acids into proteins
24:10 The challenges of identifying scalable solutions
25:27 The process behind constructing an entire synthetic chromosome
27:38 The different methods for assembling DNA
28:28 How to scale the chromosome construction process in terms of both throughput and length
30:54 The biggest barriers to a gene therapy application of this technology
32:35 The lessons learned from yeast and whether they also apply to mammalian cells
34:14 The potential application of these technologies that Leslie is most excited about
35:00 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
166 episódios
MP3•Home de episódios
Manage episode 401110078 series 2631947
Conteúdo fornecido por Sano Genetics. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Sano Genetics ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.
Summary:
0:00 Introduction
01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far
02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics
05:57 The impacts of non-coding regions of the genome and the outcome of deletions
08:20 How long it takes to make chromosomes, what does it cost, and what can we expect from the future of chromosome engineering
10:03 The inspiration behind Neochromsome and Leslie’s transition to industry from academia
13:05 From understanding the fundamentals of the genome to identifying industrial applications for genome-scale engineering
16:46 Potential gene therapy applications for the NeoYeast and NeoVector products
19:10 The power of delivering to cells using a 10-150 kilobase payload compared with lentivirus vectors
20:05 An explanation of yeast as a compact genome with few introns
21:48 How Neochrosome has developed a genome-rewritten yeast designed for incorporating non-canonical amino acids into proteins
24:10 The challenges of identifying scalable solutions
25:27 The process behind constructing an entire synthetic chromosome
27:38 The different methods for assembling DNA
28:28 How to scale the chromosome construction process in terms of both throughput and length
30:54 The biggest barriers to a gene therapy application of this technology
32:35 The lessons learned from yeast and whether they also apply to mammalian cells
34:14 The potential application of these technologies that Leslie is most excited about
35:00 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
166 episódios
All episodes
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