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EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of Human Genetics at UCSF
Manage episode 440731182 series 2631947
Conteúdo fornecido por Sano Genetics. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Sano Genetics ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.
01:15 - Introductions
02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career
04:56 - Our current understanding of non-coding genome grammar
07:40 - Is there a missing piece to the common variant, common disease paradigm?
10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)
12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?
14:25 - The potential of machine learning
16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases
20:19 - Nadav’s experience of starting a company
24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing
26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?
34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels
38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans
40:33 - Closing remarks
189 episódios
Compartilhar
Manage episode 440731182 series 2631947
Conteúdo fornecido por Sano Genetics. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Sano Genetics ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.
01:15 - Introductions
02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career
04:56 - Our current understanding of non-coding genome grammar
07:40 - Is there a missing piece to the common variant, common disease paradigm?
10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs)
12:50 - Can a simple code explain changes in certain regions of the genome? Does this require “messier” solutions, such as large language models?
14:25 - The potential of machine learning
16:56 - Using CRISPR and non-coding elements to treat haploinsufficiency-caused pediatric diseases
20:19 - Nadav’s experience of starting a company
24:44 - How CRISPR A minimizes the risks associated with traditional CRISPR editing
26:04 - How engineering fat cells can starve cancer
32:08 - What’s on the horizon for Nadav’s lab?
34:52 - Bats as unlikely “superheroes,”, and what we can learn from their glucose levels
38:43 - The genetic differences between archaic humans, like Neanderthals and Denisovans, and modern humans
40:33 - Closing remarks
189 episódios
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Parecido com The Genetics Podcast
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
…
continue reading
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…
continue reading
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
Deep in the back of your mind, you’ve always had the feeling that there’s something strange about reality. There is. Join Robert Lamb and Joe McCormick as they examine neurological quandaries, cosmic mysteries, evolutionary marvels and our transhuman future.
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
Artificial Intelligence has suddenly gone from the fringes of science to being everywhere. So how did we get here? And where's this all heading? In this new series of Science Friction, we're finding out.
…
continue reading
The Naked Scientists flagship science show brings you a lighthearted look at the latest scientific breakthroughs, interviews with the world's top scientists, answers to your science questions and science experiments to try at home.
…
continue reading
Player FM - Aplicativo de podcast
Fique off-line com o app Player FM !
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