Ep. 89: “Host-Microbiota Interactions” Featuring Dr. Theresa Alenghat

The Immunology Podcast

Guest:

Dr. Theresa Alenghat is a Professor in the Immunobiology Division and the Margaret K. Hostetter Chair at Cincinnati Children’s Hospital Medical Center, University of Cincinnati. Her lab investigates mechanisms underlying the host-microbiota relationship, and how this regulation affects intestinal immunity and inflammatory bowel disease. She discusses how butyrate affects tuft cells in the intestine.

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The Immunology Round Up

Ancient Cheese – Researchers retrieved DNA from ancient kefir cheese to study how human-microbial interactions contribute to the adaptation of domesticated lactobacilli.

Mitochondrial Movement – Mitochondrial transfer augments CD8⁺ T cell mitochondria mass and metabolic fitness.

CAR T Atlas – Scientists generated a single-cell atlas of pre-infusion CAR T cells and found that elevated type 2 functionality is associated with remission of leukemia.

NAD⁺ Reconstitution – A unique immune evasion strategy allows viruses to rebuild molecules depleted by the host’s defense system.

Image courtesy of Dr. Theresa Alenghat

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