From supply issues and vaccine hesitancy to scheduling failures and wastage, COVID19 vaccination efforts are plagued by many problems. With situation changing every week, state and local governments need to be on their toes. They need to use scalable and agile systems and processes to execute their vaccination program rapidly and safely. In this podcast, Nick Demetriades and Dr. Suman De deconstruct the challenges that state and local governments are facing as they execute their vaccination programs, and outline targeted interventions that can help them address these challenges.