298 - Understanding APOE and Alzheimer's Disease: June 2022

AMiNDR: A Month in Neurodegenerative Disease Research

Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms.

Sections in this episode:

Human Subjects Research (2:52)

AD Pathology (11:19)

Mechanism (15:12)

Targeting Memory Impairment with Genetic Manipulation (10:51)

Targeting Synaptic Function (15:17)

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To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:

https://drive.google.com/file/d/1TssyeeHICVGqw8N-Nhlt6HoYXSciPPF9/view?usp=sharing

To access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:

https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharing

You can also find all of our bibliographies on our website: www.amindr.com.

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Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don’t forget to subscribe to hear about new episodes as they come out too.

Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/.

Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Cassi Friday, edited by Michelle Grover, and reviewed by Sarah Louadi and Ellen Koch. The bibliography was made by Anjana Rajendran and the wordcloud was created by Lara Onbasi (www.wordart.com).

Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer’s Disease papers into episodes each month. For June 2022, the sorters were Sarah Louadi, Eden Dubchak, Ben Cornish, Naila Kuhlmann, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Lara Onbasi for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.

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*About AMiNDR: *

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"