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Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer

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Manage episode 396841595 series 2849974
Conteúdo fornecido por Scicomm Media. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Scicomm Media ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.

In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast.

We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan.

For show notes, including referenced articles and additional resources, please visit hubermanlab.com.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman

Eight Sleep: https://www.eightsleep.com/huberman

BetterHelp: https://betterhelp.com/huberman

Joovv: https://joovv.com/huberman

LMNT: https://drinklmnt.com/huberman

Momentous: https://livemomentous.com/huberman

Timestamps

(00:00:00) Dr. Peter Attia, Journal Club

(00:02:40) Sponsors: Eight Sleep, BetterHelp & Joovv

(00:07:14) Light, Dark & Mental Health; Retina

(00:11:16) Outdoor vs. Indoor Light, Cataracts, Sunglasses

(00:16:17) Tools: Sunrise & Sunsets, Circadian Rhythm; Midday Light

(00:24:55) Tools: Night & Light Exposure; Waking Before Sunrise

(00:31:05) Article #1, Light/Dark Exposure & Mental Health

(00:36:50) Sponsor: AG1

(00:38:18) Odds Ratio, Hazard Ratio

(00:45:43) Night vs. Daylight Exposure, Mental Health Disorders

(00:51:35) Major Depression & Light Exposure; Error Bars & Significance

(00:59:15) Sponsor: LMNT

(01:00:39) Prescriptions; Environmental & Artificial Light; Red Lights

(01:08:14) Nighttime Light Exposure; Sleep Trackers & Belief Effects

(01:13:54) Light Directionality, Phone, Night

(01:17:21) Light Wavelengths & Sensors; Sunglasses

(01:20:58) Hawthorne Effect, Reverse Causality, Genetics

(01:26:26) Artificial Sweeteners, Appetite

(01:31:16) Natural Light Cycles, Circadian Rhythm & Mental Health

(01:39:53) Article #2, Immune System & Cancer

(01:43:18) T-Cell Activation; Viruses

(01:50:41) Autoimmunity; Cancer & Immune System Evasion

(02:00:09) Checkpoint Inhibitors, CTLA-4

(02:06:45) Anti-CTLA-4 Study Drug (Ipilimumab), Melanoma

(02:12:07) Patient Population, Randomization, GP100

(02:18:09) Response Rate

(02:22:52) Overall Survival & Response

(02:28:38) Median Survival vs. Overall Survival, Drug Development

(02:35:45) Gender & Dose

(02:40:32) Adverse Events; Autoimmunity

(02:46:42) Pancreatic Cancer; Aging & Immune System Health

(02:53:57) Melanoma; Lynch Syndrome, Keytruda

(02:58:43) Immunotherapy & Cancer Treatment; Melanoma Risk

(03:06:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

Disclaimer

  continue reading

220 episódios

Artwork
iconCompartilhar
 
Manage episode 396841595 series 2849974
Conteúdo fornecido por Scicomm Media. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Scicomm Media ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.

In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast.

We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan.

For show notes, including referenced articles and additional resources, please visit hubermanlab.com.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman

Eight Sleep: https://www.eightsleep.com/huberman

BetterHelp: https://betterhelp.com/huberman

Joovv: https://joovv.com/huberman

LMNT: https://drinklmnt.com/huberman

Momentous: https://livemomentous.com/huberman

Timestamps

(00:00:00) Dr. Peter Attia, Journal Club

(00:02:40) Sponsors: Eight Sleep, BetterHelp & Joovv

(00:07:14) Light, Dark & Mental Health; Retina

(00:11:16) Outdoor vs. Indoor Light, Cataracts, Sunglasses

(00:16:17) Tools: Sunrise & Sunsets, Circadian Rhythm; Midday Light

(00:24:55) Tools: Night & Light Exposure; Waking Before Sunrise

(00:31:05) Article #1, Light/Dark Exposure & Mental Health

(00:36:50) Sponsor: AG1

(00:38:18) Odds Ratio, Hazard Ratio

(00:45:43) Night vs. Daylight Exposure, Mental Health Disorders

(00:51:35) Major Depression & Light Exposure; Error Bars & Significance

(00:59:15) Sponsor: LMNT

(01:00:39) Prescriptions; Environmental & Artificial Light; Red Lights

(01:08:14) Nighttime Light Exposure; Sleep Trackers & Belief Effects

(01:13:54) Light Directionality, Phone, Night

(01:17:21) Light Wavelengths & Sensors; Sunglasses

(01:20:58) Hawthorne Effect, Reverse Causality, Genetics

(01:26:26) Artificial Sweeteners, Appetite

(01:31:16) Natural Light Cycles, Circadian Rhythm & Mental Health

(01:39:53) Article #2, Immune System & Cancer

(01:43:18) T-Cell Activation; Viruses

(01:50:41) Autoimmunity; Cancer & Immune System Evasion

(02:00:09) Checkpoint Inhibitors, CTLA-4

(02:06:45) Anti-CTLA-4 Study Drug (Ipilimumab), Melanoma

(02:12:07) Patient Population, Randomization, GP100

(02:18:09) Response Rate

(02:22:52) Overall Survival & Response

(02:28:38) Median Survival vs. Overall Survival, Drug Development

(02:35:45) Gender & Dose

(02:40:32) Adverse Events; Autoimmunity

(02:46:42) Pancreatic Cancer; Aging & Immune System Health

(02:53:57) Melanoma; Lynch Syndrome, Keytruda

(02:58:43) Immunotherapy & Cancer Treatment; Melanoma Risk

(03:06:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

Disclaimer

  continue reading

220 episódios

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