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The future of Alzheimer’s treatment

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Manage episode 455307983 series 2712286
Conteúdo fornecido por Stanford Engineering & Russ Altman and Stanford Engineering. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Stanford Engineering & Russ Altman and Stanford Engineering ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.

Guest Michael Greicius is an authority on Alzheimer’s disease. He makes the case that while effective treatments have remained elusive, there are high hopes for new approaches that target tau proteins in the brain associated with the disease. In the meantime, to reduce Alzheimer’s risk stay active, eat well, and manage circulatory risks, but skip genetic testing for now until better treatments emerge, Greicius tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.

Episode Reference Links:

Connect With Us:

Chapters:

(00:00:00) Introduction

Russ Altman introduces guest Michael Greicius, a professor of neurology and neurological sciences at Stanford University.

(00:02:12) Understanding Alzheimer's Disease

The roles of amyloid and tau proteins in Alzheimer's disease.

(00:04:53) Challenges in Developing Treatments

The multiple hurdles in creating Alzheimer's therapies.

(00:09:07) Current Alzheimer's Drugs

The controversies and limitations of recently approved drugs.

(00:10:23) Amyloid Plaques and Their Impact

Why removing amyloid plaques hasn’t improved patient outcomes.

(00:14:29) Problems with Alzheimer's Trials

The disconnect between amyloid removal and patient outcomes.

(00:18:03) Functional Unblinding and Trial Bias

How functional unblinding affects trial results and drug evaluations.

(00:23:51) The Potential of Targeting Tau

New breakthroughs in targeting tau protein for Alzheimer’s.

(00:26:35) The Future of Prevention

Potential preemptive treatments for Alzheimer's and their administration.

(00:29:19) Lifestyle and Risk Reduction

Recommendations for reducing risk of Alzheimer’s disease.

(00:31:43) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads / Bluesky / Mastodon

Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

  continue reading

305 episódios

Artwork
iconCompartilhar
 
Manage episode 455307983 series 2712286
Conteúdo fornecido por Stanford Engineering & Russ Altman and Stanford Engineering. Todo o conteúdo do podcast, incluindo episódios, gráficos e descrições de podcast, é carregado e fornecido diretamente por Stanford Engineering & Russ Altman and Stanford Engineering ou por seu parceiro de plataforma de podcast. Se você acredita que alguém está usando seu trabalho protegido por direitos autorais sem sua permissão, siga o processo descrito aqui https://pt.player.fm/legal.

Guest Michael Greicius is an authority on Alzheimer’s disease. He makes the case that while effective treatments have remained elusive, there are high hopes for new approaches that target tau proteins in the brain associated with the disease. In the meantime, to reduce Alzheimer’s risk stay active, eat well, and manage circulatory risks, but skip genetic testing for now until better treatments emerge, Greicius tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.

Episode Reference Links:

Connect With Us:

Chapters:

(00:00:00) Introduction

Russ Altman introduces guest Michael Greicius, a professor of neurology and neurological sciences at Stanford University.

(00:02:12) Understanding Alzheimer's Disease

The roles of amyloid and tau proteins in Alzheimer's disease.

(00:04:53) Challenges in Developing Treatments

The multiple hurdles in creating Alzheimer's therapies.

(00:09:07) Current Alzheimer's Drugs

The controversies and limitations of recently approved drugs.

(00:10:23) Amyloid Plaques and Their Impact

Why removing amyloid plaques hasn’t improved patient outcomes.

(00:14:29) Problems with Alzheimer's Trials

The disconnect between amyloid removal and patient outcomes.

(00:18:03) Functional Unblinding and Trial Bias

How functional unblinding affects trial results and drug evaluations.

(00:23:51) The Potential of Targeting Tau

New breakthroughs in targeting tau protein for Alzheimer’s.

(00:26:35) The Future of Prevention

Potential preemptive treatments for Alzheimer's and their administration.

(00:29:19) Lifestyle and Risk Reduction

Recommendations for reducing risk of Alzheimer’s disease.

(00:31:43) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads / Bluesky / Mastodon

Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

  continue reading

305 episódios

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