Pursuing Prevention of Acute Lymphoblastic Leukemia (ALL) with Adam de Smith, PhD

Preventive Pros

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Adam de Smith, PhD is an assistant professor of population and public health sciences in the Department of Population and Public Health Sciences at Keck School of Medicine of USC. He is a member of the USC Center for Genetic Epidemiology and the USC Norris Comprehensive Cancer Center. de Smith is a genetic epidemiologist with a research focus on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. He leads studies investigating the role of common and rare genetic variants in ALL etiology, with a particular interest in elucidating the increased ALL risk in Latinos. He also leads a study of leukemia in children with Down syndrome, the International Study of Down Syndrome Acute Leukemia (IS-DSAL), investigating genetic and epigenetic variation associated with risk of DS-ALL. In addition, de Smith utilizes whole genome sequencing of tumors to examine potential causative agents such as DNA mutational signatures as molecular footprints of environmental exposures.
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