Unlocking the Neuroimmune Connection: Exploring Immunoception, Brain Lateralization, and the Insular Cortex with Experts Drs. Peter Scire and Rob Melillo

Inflammation Nation: Science Informed Wellness

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Why is the brain's role in immune regulation often overlooked compared to its control over the gut and hormones? Join us on Func Med Nation as we tackle this thought-provoking question with our esteemed experts Drs. Peter Scire and Rob Melillo. Together, we navigate the intriguing concept of immunosception and its vital influence on neuroimmune communication, drawing from the groundbreaking research of Kevin Tracey. As we explore the brain's impact on the immune system, we raise awareness about the critical role of neuroimmune interactions and the potential "immuno homunculus," a proposed map of these connections.
Our discussion extends into the fascinating realms of interoception and brain lateralization. We uncover how the brain perceives internal bodily states to maintain homeostasis, linking these perceptions to emotional and developmental experiences. Discover how right-brain development during early childhood can influence immune function and self-tolerance, with potential implications for understanding conditions like autism and autoimmune diseases. Peter and Rob share clinical insights, emphasizing the need for a holistic approach that values clinical presentations over standard lab tests in diagnosing immune-related issues.
The episode concludes with an exploration of the insular cortex and its role in neuroimmune interactions. We shed light on the challenges of interpreting immune responses through lab tests, especially for complex conditions. By examining real-life case studies and the intricacies of brain-immune communication, we aim to inspire Functional Medicine practitioners to deepen their understanding of this interconnected system. Join us for an enlightening conversation that bridges neuroscience and immunology, encouraging a more integrated approach to health and healing.

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Capítulos

1. Unlocking the Neuroimmune Connection: Exploring Immunoception, Brain Lateralization, and the Insular Cortex with Experts Drs. Peter Scire and Rob Melillo (00:00:00)

2. The Brain's Role in Immune Regulation (00:00:03)

3. Understanding Brain's Role in Immune Response (00:08:38)

4. Interoception and Immune Regulation (00:16:46)

5. Immunosensation and Autoimmunity (00:21:13)

6. Brain Lateralization and Immune Response (00:28:47)

7. Brainstem Influence on Gut Health (00:41:02)

8. Brain's Influence on Immune Cells (00:54:06)

9. Clinical Challenges in Immune Testing (01:02:22)

10. Immune Response and Lab Testing (01:06:17)

11. Clinical Frustrations With Lab Testing (01:10:44)

12. Exploring Insular Cortex Function and Cases (01:17:42)